Interferons (IFNs), IFN-stimulated genes (ISGs), and inflammatory cytokines mediate innate immune responses, and are essential to establish an antiviral response.Within the innate immune responses, retinoic acid-inducible gene I (RIG-I) is a key sensor of virus infections, mediating the transcriptional induction of IFNs and inflammatory proteins.Ne
ABSTRAK Sebagai wadah kerja sama regional Asia Tenggara, ASEAN tengah memasuki suatu tahapan penting dalam proses peningkatan kerja sama kawasan.Tahapan tersebut merupakan salah satu respon dari perkembangan yang terjadi dalam era globalisasi dan perdagangan bebas.Berbekal dengan semangat awal pembentukan ASEAN yang berdasarkan tiga pilar kerja sam
Combinatorial library of novel benzenesulfonamides was docked (Schrodinger Glide) into mycobacterial carbonic anhydrase (mtCA II) and human (hCA II) isoforms with an aim to find drug candidates with selective activity on mtCA Womens Shacket II.The predicted selectivity was calculated based on optimized MM-GBSA free energies for ligand enzyme intera
Apical neural progenitors (aNPs) drive neurogenesis by means of a program consisting of self-proliferative and neurogenic divisions.The balance between these two manners of division sustains the pool of apical progenitors into late neurogenesis, thereby ensuring their availability to populate the brain with terminal cell types.Using knockout and in